Michele Cea Selected Research

N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamide

11/2019	Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent.
9/2015	APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.
11/2010	Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
6/2009	APO866 activity in hematologic malignancies: a preclinical in vitro study.

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Michele Cea Research Topics

Disease

38	Neoplasms (Cancer) 09/2022 - 11/2009
19	Multiple Myeloma 01/2022 - 08/2012
8	Hematologic Neoplasms (Hematological Malignancy) 10/2020 - 06/2009
7	Breast Neoplasms (Breast Cancer) 12/2020 - 02/2010
7	Leukemia 10/2020 - 11/2010
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2021 - 09/2015
4	Pancreatic Neoplasms (Pancreatic Cancer) 04/2018 - 11/2012
4	Inflammation (Inflammations) 01/2016 - 11/2012
2	Adenocarcinoma 09/2022 - 04/2018
2	Residual Neoplasm 11/2021 - 01/2019
2	Carcinogenesis 10/2020 - 01/2016
2	Paraproteinemias (Monoclonal Gammopathy) 01/2020 - 10/2004
2	Starvation 01/2020 - 05/2015
2	Lymphoma (Lymphomas) 01/2020 - 01/2010
2	Genomic Instability 03/2016 - 01/2015
2	Atherosclerosis 01/2016 - 09/2015
2	Neoplasm Metastasis (Metastasis) 01/2016 - 07/2015
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 09/2015 - 11/2010
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2013 - 09/2010
1	Neutropenia 12/2021
1	Infections 12/2021
1	Pneumonia (Pneumonitis) 12/2021
1	Chromosome Aberrations (Chromosome Abnormalities) 02/2021
1	Hodgkin Disease (Hodgkin's Disease) 01/2021
1	Endometrial Hyperplasia 01/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2020
1	Lipoma (Lipomata) 10/2019

Drug/Important Bio-Agent (IBA)

14	NAD (NADH)IBA 01/2019 - 11/2009
9	Nicotinamide PhosphoribosyltransferaseIBA 09/2022 - 11/2009
9	Biological ProductsIBA 01/2020 - 10/2012
6	EnzymesIBA 01/2017 - 10/2012
5	Proteins (Proteins, Gene)FDA Link 10/2020 - 12/2014
4	Bortezomib (Velcade)FDA Link 12/2021 - 08/2013
4	N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamideIBA 11/2019 - 06/2009
3	Dexamethasone (Maxidex)FDA LinkGeneric 12/2021 - 01/2020
3	carfilzomibIBA 12/2021 - 01/2020
3	Adenosine Triphosphate (ATP)IBA 01/2021 - 11/2010
3	Tyrosine Kinase InhibitorsIBA 10/2020 - 03/2010
3	ibrutinibIBA 10/2020 - 08/2012
3	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2020 - 01/2018
3	Pharmaceutical PreparationsIBA 10/2017 - 09/2015
3	SirtuinsIBA 01/2017 - 01/2011
3	Histone Deacetylases (Histone Deacetylase)IBA 03/2016 - 01/2011
3	Lapatinib (GW572016)FDA Link 05/2015 - 02/2010
2	Lenalidomide (CC 5013)FDA Link 12/2021 - 02/2021
2	ChemokinesIBA 08/2021 - 11/2012
2	Antineoplastic Agents (Antineoplastics)IBA 08/2021 - 12/2014
2	Hormones (Hormone)IBA 12/2020 - 01/2020
2	Agammaglobulinaemia Tyrosine KinaseIBA 10/2020 - 08/2012
2	Rituximab (Mabthera)FDA Link 01/2020 - 01/2010
2	Mechanistic Target of Rapamycin Complex 1IBA 10/2019 - 10/2012
2	pyrrolidineIBA 04/2018 - 05/2010
2	LipidsIBA 04/2018 - 09/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 01/2015
2	B-Cell Maturation AntigenIBA 01/2016 - 05/2014
2	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2016 - 05/2014
2	Monoclonal AntibodiesIBA 05/2014 - 01/2010
2	Histone Deacetylase InhibitorsIBA 01/2013 - 01/2011
2	Vorinostat FDA Link 01/2013 - 01/2011
1	venetoclaxIBA 01/2022
1	ixazomibIBA 12/2021
1	daratumumabIBA 12/2021
1	Thalidomide (Thalomid)FDA Link 12/2021
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2021
1	Melphalan (Alkeran)FDA LinkGeneric 12/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2021
1	AdipokinesIBA 08/2021
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 01/2021
1	NivolumabIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	ARQ531IBA 10/2020
1	Phosphotransferases (Kinase)IBA 10/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2020
1	RNA (Ribonucleic Acid)IBA 10/2020
1	Tyrosine (L-Tyrosine)FDA Link 10/2020
1	Untranslated RNA (Noncoding RNA)IBA 01/2020
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2020
1	Fulvestrant (Faslodex)FDA Link 01/2020
1	Amino Acids FDA Link 01/2020
1	Asparaginase (Elspar)FDA Link 01/2020
1	Cisplatin (Platino)FDA LinkGeneric 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2020
1	Tamoxifen FDA LinkGeneric 01/2020
1	LeptinIBA 01/2020
1	Long Noncoding RNAIBA 01/2020
1	Sirolimus (Rapamycin)FDA Link 10/2019
1	AlpelisibIBA 10/2019
1	fludarabineIBA 01/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019
1	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 01/2019

Therapy/Procedure

8	Therapeutics 02/2021 - 01/2010
4	Stem Cell Transplantation 12/2021 - 01/2021
3	Radiotherapy 10/2018 - 05/2015
2	Drug Therapy (Chemotherapy) 09/2022 - 07/2015
2	Transplantation 12/2021 - 01/2020
2	Autologous Transplantation 12/2021 - 09/2021
1	Salvage Therapy 01/2021